Journal article
A Comparison of Glucose and Additional Signals for Three Different Exercise Types in Adolescents with Type 1 Diabetes Using a Hybrid Closed-Loop System
R Seckold, CE Smart, DN O’Neal, MC Riddell, J Rafferty, D Morrison, V Obeyesekere, JL Gooley, B Paldus, SR Valkenborghs, S Vogrin, DP Zaharieva, BR King
Diabetes Technology and Therapeutics | MARY ANN LIEBERT, INC | Published : 2025
Abstract
Objective: To compare glycemic outcomes during and following moderate-intensity exercise (MIE), high-intensity interval exercise (HIE), and resistance exercise (RE) in adolescents with type 1 diabetes (T1D) using a hybrid closed-loop (HCL) insulin pump while measuring additional physiological signals associated with activity. Methods: Twenty-eight adolescents (average age 16.3 – 2.1 years, 50% females, average duration of T1D 9.4 – 4 years) using HCL (Medtronic MiniMed 670G) undertook 40 min of MIE, HIE, and RE. A temporary glucose target (8.3 mmol/L, 150 mg/dL) was set for 2 h prior and during exercise. Heart rate, accelerometer, venous glucose, lactate, ketones, and counter-regulatory horm..
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Grants
Awarded by Dexcom
Funding Acknowledgements
This trial was funded by the Leona M. and Harry B. Helmsley Charitable Trust and JDRF International (3-SRA-2018-532-M-B). In-kind support was provided by Medtronic (HCLsystems and technical expertise with device issues). JDRF Australia provided input into the trial design. The funders of the trial had no role in data collection, data analysis, data interpretation, or writing of the report.